CD138+ Plasma Cell Enrichment from Whole Blood and Bone Marrow

CD138 expression is a hallmark of plasma cells and multiple myeloma cells, and it is considered a useful marker in plasma cells tumors diagnostics. Using our newly developed MARS® CS system (multi-physics automated reconfigurable separation) we demonstrate a cost-efficient, fast and robust workflow for isolation of CD138+ cells from whole blood and bone marrow samples within a short […]

A New Approach for High Recovery and Purity Isolation of Plasma Cells from Whole Blood

Characterization of Plasma Cells in Bone Marrow for different cytogenetic abnormalities is a common genetic test to diagnose and monitor cell malignant disease such as multiple myeloma (MM). Plasma cells in MM patients varied in proportion from <1% up to 100%. For the less invasive sample collection, circulating plasma cells (CPCs) in peripheral blood have emerged as an important […]

Mouse Brain Tumor Cells Pre-Enrichment for Increased FACS Throughput

The new MARS acoustic technology utilizes active-microfluidics acoustics for the separation of single cells or nuclei without labeling, based only on the difference in their physical parameters. The cells are isolated with high recovery and ready for flow sorting, single-cell genomics and many other applications. 

Singulator® and MARS®: Efficient Nuclei Isolation from a Variety of Tissue Samples

MARS acoustic technology utilizes active-microfluidics acoustics for the separation of single cells or nuclei without labeling, based only on the difference in their physical parameters. The cells are isolated with high recovery and ready for single-cell genomics. The Singulator System automates the processing of solid tissue samples into suspensions of single cells or nuclei with high […]

B cell isolation with MARS® Platform

Immunotherapy requires purified cells for a variety of experimental needs. For patients with protein deficiencies for whom gene therapy is not an option, B cells provide an excellent factory for producing immunoglobulin in lymphocytes or plasma cells. x`Obtaining a large number of B cells requires a cell isolation solution for both pre-clinical testing on a […]

Multiphysics innovation for high speed, high recovery, and high viability automated cell separation

INTRODUCTION Tumor biology, immunology, and immune-oncology from multi-omics at the single cell level have witnessed an unprecedented acceleration in recent years, with a major contribution of such speedup from new technologies and products bursting into the market. New technological solutions also contributed deterministically to the promise of cell-based therapy. However, conventional cell separation tools, such […]

Novel Multiphysics Cell Separation Platforms for Cell Therapy Development

INTRODUCTION In the past twenty years, cell therapy has made great success in treating patients and enormous efforts have been devoted to developing new drugs as well as improving the efficiency of manufacturing processes. New technological solutions with flexibility and scalability are desired to support the promise of cell-based therapy. MARS Cell Separation Platforms incorporate […]

Acoustic cell separation platform for efficient preparation of single cell/nuclei suspension from complex samples for genomics analysis

INTRODUCTION The scale and capabilities of single-cell RNA-sequencing methods have expanded rapidly in recent years, enabling major discoveries and large-scale cell mapping efforts. Sample types go beyond simple cultured cell line cells and blood cells to all types of tissues: fresh or frozen. In certain cell types, single nuclei isolation is much easier than single […]

NK cell isolation with MARS® Platform

Over the last years, NK cells have gained significant attention in the field of cancer immunotherapy and many efforts are emerging for developing and engineering NK cell-based cancer immunotherapy. Obtaining a large quantity of NK cells requires a democratized cell isolation solution for both pre-clinical and clinical applications. The new MARS Bar system enables a […]