Efficient TIL cell isolation from biopsy samples is important for academic and clinical research. Using our newly developed MARS system (multi-physics automated reconfigurable separation) we demonstrated a label-free automated process to isolate TIL cells directly from a dissociated tissue sample. With MARS Separation, we separated tumor cells as well as dead cells and debris from TIL cells to isolate pure TIL cells from lung tumor biopsy. MARS can be placed in a biosafety cabinet to perform sterile TIL cell isolation for further functional studies.
