INTRODUCTION
Adoptive cell therapy has proven clinical efficacy in many cancer types and the success has driven more development of new drugs. However, on the manufacturing side, current process using conventional tools is complicated and results in suboptimal purity and yield sometimes. All those shortcomings may contribute to the high cost of the cell products and limit the patients access to drugs. Cell therapy developers in both industry and academic settings are trying to improve their manufacturing process aiming to increase efficiency and lower cost. Cell selection done with magnetic beads antibody conjugate is an important step in cell manufacturing: it is either the first step to isolate T cells for gene modification or the last step to deplete subtype of T cells in allogenic transplantation, so a fast efficient magnetic cell separation system has been desired. We have developed an automated closed system (MARS® BAR) based on Applied Cells proprietary column-free matrix-free in-flow magnetic cell separation technology. The system can deal with diverse cell sources without requiring cell washing before or after labeling, thus it makes the cell selection workflow very simple. The MARS® BAR system has no capacity limit and is easy to scale-down or scale-up, which makes it suitable for both autologous and allogenic cell therapy manufacture.
This poster was presented at the ASGCT 26th Annual Meeting in Los Angeles, CA.
