Multiphysics innovation for high speed, high recovery, and high viability automated cell separation

INTRODUCTION
Tumor biology, immunology, and immune-oncology from multi-omics at the single cell level have witnessed an unprecedented acceleration in recent years, with a major contribution of such speedup from new technologies and products bursting into the market. New technological solutions also contributed deterministically to the promise of cell-based therapy. However, conventional cell separation tools, such as density-gradient-based centrifugation, column-based magnetic cell separation, and even FACS (fluorescent activated cell sorting) have become limiting factors to broadening the application of single cell analysis from complex tissues samples and very rare cell types. In the development of cell therapy drugs, robust cell manufacturing platforms that are flexible, adaptable to various processes, and involve minimal human factors, are also widely sought after.