WHY ARE WE DEVELOPING INGENUITYâ„¢ PLUS?

Ingenuityâ„¢ Plus: Prototype Sterile Reagent Transfer Device

Ingenuityâ„¢ Plus is a prototype sterile reagent transfer device under development for cell therapy and bioprocessing workflows. It is being evaluated for its potential to support closed reagent handling and reduce dependence on Class A environments in certain applications, subject to validation and process-specific requirements.

Contact us to discuss co-development opportunities

PROTOTYPE CONFIGURATIONS UNDER EVALUATION

Prototype Concept 1: Ingenuity Plus with Packaged Reagent Format

  • Being evaluated with Applied Cells reagent formats
  • Designed to reduce user-side vial installation steps
  • Prototype format under evaluation for ready-to-use sterile presentation
  • Documentation approach, including traceability and sterility support, is under development
  • Intended for evaluation with partners interested in traceability and workflow simplicity

Prototype Concept 2: Ingenuity Plus Sterile Device for User-Supplied Reagents

  • Designed for evaluation with compatible user-selected ISO vials
  • Prototype workflow may include guidance for:
    • Vial sterilization
    • Vial installation
    • Final device sealing
  • May be provided as a sterile bagged prototype device for user-side reagent assembly
  • Users would remain responsible for reagent-side sterility strategy and batch documentation

Why We Are Developing Ingenuityâ„¢ Plus

Developed to help reduce contamination risk

Designed with GMP-aligned workflows in mind

Flexibility across ready-to-use and user-customized reagent approaches

Packaged Reagent Prototype Concept from Applied Cells Sterile Device Prototype Concept without Reagent

Reagents

Applied Cells reagent format under evaluation for cell therapy workflows
User-selected reagents in compatible ISO vials

Vial Install

Intended to minimize user installation steps
Prototype workflow guidance may be provided for:
(1) Reagent vial sterilization
(2) Vial installation in device
(3) Sterile sealing of device

Sterility

Documentation and sterility support approach under evaluation
User remains responsible for batch record and sterility control

Product Format

Prototype packaged reagent configuration under evaluation
Sterile bagged prototype device for user assembly with own reagents

Price

Ingenuity Plus Reagents list price
Contact us info@appliedcells.com

Why Choose Ingenuityâ„¢ Plus?

  • Reduces risk of contamination

  • Supports GMP-compliant workflows

  • Offers flexibility with ready-to-use or user-customized formats

  • Saves time on reagent preparation

Ingenuity Plus
with
Packaged reagents
from
Applied Cells
Ingenuity Plus
Sterile Device
without reagent

Reagents

Applied Cells GMP reagents for Cell Therapy use
Reagents in compatible ISO vials of your own choice

Vial Install

No need
You will be provided instructions:
(1) Reagents vials sterilization
(2) Install of vials in device
(3) Sterile sealing of device

Sterility

Comes with batch record and sterility report
You are responsible for batch record and sterility control

Product Format

Applied Cells Ingenuity reagents inside sterile device ready for use
Bagged sterilized Ingenuity Plus device for user assembly of own reagents

Price

Ingenuity Plus Reagents list price
Contact us info@appliedcells.com

AUTOMATION MEETS INNOVATION

MARS® Bar – one platform for both T cell enrichment and CAR-T cell harvest

  • Column-free, closed, sterile fluidics system
  • ISO 13485:2016 certified and GMP-ready
  • Compatible with fresh or frozen leukopak
  • Solution optimized for Applied Cells’ IngenuityTM reagents

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