Enhancing Diagnostic Precision in Multiple Myeloma

Innovative solutions that improve diagnostic precision in multiple myeloma patients have potential to improve patient care and research outcomes. In this study we introduced a streamlined method for isolating CD138+ cells for multiple myeloma (MM) diagnosis and cytogenetic analysis. Using CD138 microbeads and the MARS BAR Flex platform, we achieved high recovery rates, purity, and […]

Efficient CTC enrichment with column-free MARS Bar Platform

Efficient CTC purification using CD45 depletion with MARS® Bar technology advances cancer research.

Purifying circulating tumor cells (CTCs) is vital for cancer research advancement and new diagnostic and therapeutic strategies. High-purity CTC isolation provides critical insights into tumor biology, metastasis, and treatment response. CTCs are invaluable for personalized medicine development, biomarker discovery, and therapeutic testing. Here, we introduce a rapid and effective CTC isolation method using CD45 depletion […]

MARS® Ingenuity™ Line of Reagents brochure

MARS® Ingenuity™ Reagent kits offer comprehensive solutions for the advancement of global cell therapy research, development and manufacturing. Designed with both Research Use Only (RUO) and GMP-grade reagents, these kits provide a fast and straightforward approach to cell isolation, supporting a wide range of therapies including CAR-T, immune cell-based therapies, stem cell-based therapies, and cancer […]

T cell Isolation using CD3/CD28 microbeads

Application note showcasing Column-Free CD3/CD28+ T cell Isolation using 50nm Superparamagentic Beads on MARS® Bar

The success of CAR T cell therapy in blood cancers highlights the need to optimize manufacturing for wider access, and efficient T cell isolation is crucial, impacting therapy effectiveness. Demand for better isolation methods is rising. CD3/CD28 microbeads are gaining attention for simplifying processes and enhancing workflow. They activate a wide range of T cells, […]

AACR 2024: A Novel Automated Platform for Rapid Manufacturing of CAR-T Cells

AACR 2024 poster introducing A new Automated MARS Platform for Rapid Manufacturing of CAR-T Cells by Applied Cells

Autologous cell therapy using T cells that are genetically modified to express a chimeric antigen receptor (CAR) has yielded durable responses in patients with cancers. However, globally only a small fraction of eligible patients are privileged to receive the treatment. High cost and long manufacturing time contribute to the key limitations prohibiting a broad adoption […]

Column-Free CD14+ Monocyte Isolation using 50nm Superparamagentic Beads on MARS® Bar

Application note showcasing Column-Free Monocyte Isolation using 50nm Superparamagentic Beads on MARS® Bar

Dendritic cells are professional antigen-presenting cells and they play a key role in the regulation of immune responses. Dendritic cells are widely used as vaccines and drugs for cancer treatment in a large number of trials. Macrophages are essential innate immune cells and when activated, macrophages can mediate the phagocytosis of dangerous cells or materials […]

Column-Free T cell Isolation using 50nm Superparamagentic Beads on MARS® Bar

Application note showcasing Column-Free T cell Isolation using 50nm Superparamagentic Beads on MARS® Bar

 The therapeutic efficacy of CAR T cells has been firmly established in hematologic malignancies and the key is to develop a low-cost manufacturing process to enable the wide adoption of the therapy. T cell isolation being upstream process for CAR T cell manufacturing has significant impact on the quality of the T cells and the […]

CD34+ Cell Isolation from Cord Blood MNC

Application note highlighting benefits of CD34+ Cell Isolation from Cord Blood Mononuclear Cells (MNC) from Applied Cells MARS Bar

 CD34+ cells offer valuable insights into hematopoiesis, hematological disorders, and regenerative medicine. They have potential in cancer therapies, autoimmune diseases, and genetic disorders. Isolating CD34+ cells from Cord Blood Mononuclear Cells (MNC) is crucial for research in hematopoietic stem cell biology and therapeutic advancements. MARS® Platform ensures the enrichment of CD34+ cells, enhancing purity, viability, […]