ASGCT 2023: Simple magnetic cell separation for both autologous and allogenic cell therapy development
INTRODUCTION Adoptive cell therapy has proven clinical efficacy in many cancer types and the success has driven more development of new drugs. However, on the manufacturing side, current process using conventional tools is complicated and results in suboptimal purity and yield sometimes. All those shortcomings may contribute to the high cost of the cell products […]
Simple magnetic cell separation enabled by an automated, closed system for both autologous and allogenic cell therapy development
INTRODUCTION Adoptive cell therapy has demonstrated effective clinical results in various types of cancer, leading to increased efforts in developing new drugs. However, the current manufacturing process using conventional tools is complex and often yields impure products, contributing to the high cost of cell therapy and limiting patient access. Both industry and academic cell therapy […]
Multiphysics innovation for high speed, high recovery, and high viability automated cell separation
INTRODUCTION Tumor biology, immunology, and immune-oncology from multi-omics at the single cell level have witnessed an unprecedented acceleration in recent years, with a major contribution of such speedup from new technologies and products bursting into the market. New technological solutions also contributed deterministically to the promise of cell-based therapy. However, conventional cell separation tools, such […]
Novel Multiphysics Cell Separation Platforms for Cell Therapy Development
INTRODUCTION In the past twenty years, cell therapy has made great success in treating patients and enormous efforts have been devoted to developing new drugs as well as improving the efficiency of manufacturing processes. New technological solutions with flexibility and scalability are desired to support the promise of cell-based therapy. MARS Cell Separation Platforms incorporate […]
High Performance Large Scale T Cell Isolation with MARS
Efficient T cell isolation with high recovery and high purity is important for academic and clinical research. Using our newly developed MARS system (multi-physics automated reconfigurable separation) we demonstrate an automated process to isolate T cells within a short time. With MARS Bar, we achieved greater than 95% purity of T cells isolated from a […]