骨髓浆细胞(BM)的细胞遗传学特异性特征是诊断和监测多发性骨髓瘤(MM)的一种常见的基因检测方法。多发性骨髓瘤患者的浆细 胞比例从1%到100%不等。尽管有些研究显示外周血中循环浆细胞(CPCs)比在骨髓中的风险低100倍以上,但由于其样本采集的侵入性 较低,它们的存在仍被认为是多发性骨髓瘤患者预后的一个重要标志。然而,耗时的样品制备步骤和在此过程中大量的细胞损失仍是一 个重大的挑战。MARS®平台通过一种简单的方法从外周血中分离CD138+浆细胞,而不需要RBC裂解和密度梯度离心。
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